Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives.
Identifieur interne : 000653 ( Main/Exploration ); précédent : 000652; suivant : 000654Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives.
Auteurs : Zhaoqian Fan [République populaire de Chine] ; Yukun Qin [République populaire de Chine] ; Song Liu [République populaire de Chine] ; Ronge Xing [République populaire de Chine] ; Huahua Yu [République populaire de Chine] ; Xiaolin Chen [République populaire de Chine] ; Kecheng Li [République populaire de Chine] ; Pengcheng Li [République populaire de Chine]Source :
- Carbohydrate polymers [ 1879-1344 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antifongiques (composition chimique), Antifongiques (pharmacologie), Antifongiques (synthèse chimique), Antifongiques (toxicité), Cellules HepG2 (MeSH), Cellules RAW 264.7 (MeSH), Champignons (effets des médicaments et des substances chimiques), Chitosane (composition chimique), Chitosane (pharmacologie), Chitosane (synthèse chimique), Chitosane (toxicité), Conformation moléculaire (MeSH), Humains (MeSH), Modèles moléculaires (MeSH), Plantes (microbiologie), Relation structure-activité (MeSH), Solubilité (MeSH), Souris (MeSH), Survie cellulaire (effets des médicaments et des substances chimiques), Techniques de chimie synthétique (MeSH), Tests de sensibilité microbienne (MeSH).
- MESH :
- composition chimique : Antifongiques, Chitosane.
- effets des médicaments et des substances chimiques : Champignons, Survie cellulaire.
- microbiologie : Plantes.
- pharmacologie : Antifongiques, Chitosane.
- synthèse chimique : Antifongiques, Chitosane.
- toxicité : Antifongiques, Chitosane.
- Animaux, Cellules HepG2, Cellules RAW 264.7, Conformation moléculaire, Humains, Modèles moléculaires, Relation structure-activité, Solubilité, Souris, Techniques de chimie synthétique, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Animals (MeSH), Antifungal Agents (chemical synthesis), Antifungal Agents (chemistry), Antifungal Agents (pharmacology), Antifungal Agents (toxicity), Cell Survival (drug effects), Chemistry Techniques, Synthetic (MeSH), Chitosan (chemical synthesis), Chitosan (chemistry), Chitosan (pharmacology), Chitosan (toxicity), Fungi (drug effects), Hep G2 Cells (MeSH), Humans (MeSH), Mice (MeSH), Microbial Sensitivity Tests (MeSH), Models, Molecular (MeSH), Molecular Conformation (MeSH), Plants (microbiology), RAW 264.7 Cells (MeSH), Solubility (MeSH), Structure-Activity Relationship (MeSH).
- MESH :
- chemical , chemical synthesis : Antifungal Agents, Chitosan.
- chemical , chemistry : Antifungal Agents, Chitosan.
- chemical , pharmacology : Antifungal Agents, Chitosan.
- chemical , toxicity : Antifungal Agents, Chitosan.
- drug effects : Cell Survival, Fungi.
- microbiology : Plants.
- Animals, Chemistry Techniques, Synthetic, Hep G2 Cells, Humans, Mice, Microbial Sensitivity Tests, Models, Molecular, Molecular Conformation, RAW 264.7 Cells, Solubility, Structure-Activity Relationship.
Abstract
Botrytis cinerea, Phytophthora capsici Leonian, and Fusarium solani are important plant pathogenic fungi which can cause great crop losses worldwide, but their control methods are limited. It is necessary to develop efficient and green fungicides from abundant marine resources. Chitosan is a non-toxic, biodegradable, biocompatible marine polysaccharide which has prospective applications in agriculture. In this paper, to increase the antifungal activity of chitosan for application, novel water-soluble functional chitosan derivatives were synthesized by grafting polyaminoethyl and diethoxyphosphoryl groups in accordance with a strategy of improving protonation potential. The derivatives were characterized by FTIR, NMR, XRD, SEM, Gaussian 09 and elemental analysis. The antifungal activities against the three fungi and the cytotoxicity were estimated in vitro. The results showed that the derivatives had better antifungal activities and water solubility than chitosan, and had good biocompatibility. They confirmed that these chitosan derivatives can be developed as antifungal agents for plant protection purposes.
DOI: 10.1016/j.carbpol.2018.02.056
PubMed: 29628225
Affiliations:
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Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="Li, Kecheng" sort="Li, Kecheng" uniqKey="Li K" first="Kecheng" last="Li">Kecheng Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="Li, Pengcheng" sort="Li, Pengcheng" uniqKey="Li P" first="Pengcheng" last="Li">Pengcheng Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China. 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Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="Xing, Ronge" sort="Xing, Ronge" uniqKey="Xing R" first="Ronge" last="Xing">Ronge Xing</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Huahua" sort="Yu, Huahua" uniqKey="Yu H" first="Huahua" last="Yu">Huahua Yu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xiaolin" sort="Chen, Xiaolin" uniqKey="Chen X" first="Xiaolin" last="Chen">Xiaolin Chen</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="Li, Kecheng" sort="Li, Kecheng" uniqKey="Li K" first="Kecheng" last="Li">Kecheng Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="Li, Pengcheng" sort="Li, Pengcheng" uniqKey="Li P" first="Pengcheng" last="Li">Pengcheng Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China. Electronic address: pcli@qdio.ac.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author></analytic><series><title level="j">Carbohydrate polymers</title><idno type="eISSN">1879-1344</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antifungal Agents (chemical synthesis)</term><term>Antifungal Agents (chemistry)</term><term>Antifungal Agents (pharmacology)</term><term>Antifungal Agents (toxicity)</term><term>Cell Survival (drug effects)</term><term>Chemistry Techniques, Synthetic (MeSH)</term><term>Chitosan (chemical synthesis)</term><term>Chitosan (chemistry)</term><term>Chitosan (pharmacology)</term><term>Chitosan (toxicity)</term><term>Fungi (drug effects)</term><term>Hep G2 Cells (MeSH)</term><term>Humans (MeSH)</term><term>Mice (MeSH)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Models, Molecular (MeSH)</term><term>Molecular Conformation (MeSH)</term><term>Plants (microbiology)</term><term>RAW 264.7 Cells (MeSH)</term><term>Solubility (MeSH)</term><term>Structure-Activity Relationship (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antifongiques (composition chimique)</term><term>Antifongiques (pharmacologie)</term><term>Antifongiques (synthèse chimique)</term><term>Antifongiques (toxicité)</term><term>Cellules HepG2 (MeSH)</term><term>Cellules RAW 264.7 (MeSH)</term><term>Champignons (effets des médicaments et des substances chimiques)</term><term>Chitosane (composition chimique)</term><term>Chitosane (pharmacologie)</term><term>Chitosane (synthèse chimique)</term><term>Chitosane (toxicité)</term><term>Conformation moléculaire (MeSH)</term><term>Humains (MeSH)</term><term>Modèles moléculaires (MeSH)</term><term>Plantes (microbiologie)</term><term>Relation structure-activité (MeSH)</term><term>Solubilité (MeSH)</term><term>Souris (MeSH)</term><term>Survie cellulaire (effets des médicaments et des substances chimiques)</term><term>Techniques de chimie synthétique (MeSH)</term><term>Tests de sensibilité microbienne (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antifungal Agents</term><term>Chitosan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antifungal Agents</term><term>Chitosan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antifungal Agents</term><term>Chitosan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antifungal Agents</term><term>Chitosan</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Antifongiques</term><term>Chitosane</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Fungi</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Champignons</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plants</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antifongiques</term><term>Chitosane</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antifongiques</term><term>Chitosane</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Antifongiques</term><term>Chitosane</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chemistry Techniques, Synthetic</term><term>Hep G2 Cells</term><term>Humans</term><term>Mice</term><term>Microbial Sensitivity Tests</term><term>Models, Molecular</term><term>Molecular Conformation</term><term>RAW 264.7 Cells</term><term>Solubility</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules HepG2</term><term>Cellules RAW 264.7</term><term>Conformation moléculaire</term><term>Humains</term><term>Modèles moléculaires</term><term>Relation structure-activité</term><term>Solubilité</term><term>Souris</term><term>Techniques de chimie synthétique</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Botrytis cinerea, Phytophthora capsici Leonian, and Fusarium solani are important plant pathogenic fungi which can cause great crop losses worldwide, but their control methods are limited. It is necessary to develop efficient and green fungicides from abundant marine resources. Chitosan is a non-toxic, biodegradable, biocompatible marine polysaccharide which has prospective applications in agriculture. In this paper, to increase the antifungal activity of chitosan for application, novel water-soluble functional chitosan derivatives were synthesized by grafting polyaminoethyl and diethoxyphosphoryl groups in accordance with a strategy of improving protonation potential. The derivatives were characterized by FTIR, NMR, XRD, SEM, Gaussian 09 and elemental analysis. The antifungal activities against the three fungi and the cytotoxicity were estimated in vitro. The results showed that the derivatives had better antifungal activities and water solubility than chitosan, and had good biocompatibility. They confirmed that these chitosan derivatives can be developed as antifungal agents for plant protection purposes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29628225</PMID><DateCompleted><Year>2018</Year><Month>09</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>09</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1344</ISSN><JournalIssue CitedMedium="Internet"><Volume>190</Volume><PubDate><Year>2018</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>Carbohydrate polymers</Title><ISOAbbreviation>Carbohydr Polym</ISOAbbreviation></Journal><ArticleTitle>Synthesis, characterization, and antifungal evaluation of diethoxyphosphoryl polyaminoethyl chitosan derivatives.</ArticleTitle><Pagination><MedlinePgn>1-11</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0144-8617(18)30214-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.carbpol.2018.02.056</ELocationID><Abstract><AbstractText>Botrytis cinerea, Phytophthora capsici Leonian, and Fusarium solani are important plant pathogenic fungi which can cause great crop losses worldwide, but their control methods are limited. It is necessary to develop efficient and green fungicides from abundant marine resources. Chitosan is a non-toxic, biodegradable, biocompatible marine polysaccharide which has prospective applications in agriculture. In this paper, to increase the antifungal activity of chitosan for application, novel water-soluble functional chitosan derivatives were synthesized by grafting polyaminoethyl and diethoxyphosphoryl groups in accordance with a strategy of improving protonation potential. The derivatives were characterized by FTIR, NMR, XRD, SEM, Gaussian 09 and elemental analysis. The antifungal activities against the three fungi and the cytotoxicity were estimated in vitro. The results showed that the derivatives had better antifungal activities and water solubility than chitosan, and had good biocompatibility. They confirmed that these chitosan derivatives can be developed as antifungal agents for plant protection purposes.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Zhaoqian</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China; University of Chinese Academy of Sciences, Beijing 100049, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Yukun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China. Electronic address: ykqin@qdio.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Song</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Ronge</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Huahua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiaolin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Kecheng</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Pengcheng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, No. 1 Wenhai Road, Qingdao 266237, China. Electronic address: pcli@qdio.ac.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>02</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Carbohydr Polym</MedlineTA><NlmUniqueID>8307156</NlmUniqueID><ISSNLinking>0144-8617</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>9012-76-4</RegistryNumber><NameOfSubstance UI="D048271">Chitosan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060326" MajorTopicYN="N">Chemistry Techniques, Synthetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048271" MajorTopicYN="N">Chitosan</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="Y">chemical synthesis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056945" MajorTopicYN="N">Hep G2 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008968" MajorTopicYN="N">Molecular Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012995" MajorTopicYN="N">Solubility</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antifungal</Keyword><Keyword MajorTopicYN="N">Chitosan</Keyword><Keyword MajorTopicYN="N">Phosphoryl</Keyword><Keyword MajorTopicYN="N">Polyaminoethyl</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>10</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>02</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>02</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>9</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29628225</ArticleId><ArticleId IdType="pii">S0144-8617(18)30214-5</ArticleId><ArticleId IdType="doi">10.1016/j.carbpol.2018.02.056</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Fan, Zhaoqian" sort="Fan, Zhaoqian" uniqKey="Fan Z" first="Zhaoqian" last="Fan">Zhaoqian Fan</name></noRegion><name sortKey="Chen, Xiaolin" sort="Chen, Xiaolin" uniqKey="Chen X" first="Xiaolin" last="Chen">Xiaolin Chen</name><name sortKey="Li, Kecheng" sort="Li, Kecheng" uniqKey="Li K" first="Kecheng" last="Li">Kecheng Li</name><name sortKey="Li, Pengcheng" sort="Li, Pengcheng" uniqKey="Li P" first="Pengcheng" last="Li">Pengcheng Li</name><name sortKey="Liu, Song" sort="Liu, Song" uniqKey="Liu S" first="Song" last="Liu">Song Liu</name><name sortKey="Qin, Yukun" sort="Qin, Yukun" uniqKey="Qin Y" first="Yukun" last="Qin">Yukun Qin</name><name sortKey="Xing, Ronge" sort="Xing, Ronge" uniqKey="Xing R" first="Ronge" last="Xing">Ronge Xing</name><name sortKey="Yu, Huahua" sort="Yu, Huahua" uniqKey="Yu H" first="Huahua" last="Yu">Huahua Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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